Published January 1, 2024
| Version v1
Journal article
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Rationally reprogramming single-cell aging trajectories and lifespan through dynamic modulation of environmental inputs
Creators
- 1. Flatiron Inst, Ctr Computat Biol, New York, NY USA
- 2. Inst Genet & Biol Mol & Cellulaire, Illkirch Graffenstaden, France
Description
How do variations in nutrient levels influence cellular lifespan? A dynamical systems model of a core circuit involved in yeast aging suggests principles underlying lifespan extension observed at static and alternating glucose levels that are reminiscent of intermittent fasting regimens.
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