Published January 1, 2010
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Ultrafast and sensitive bioassay using split ring resonator structures and microwave heating
Creators
- 1. Bilkent Univ, Dept Phys, Dept Elect & Elect Engn, Nanotechnol Res Ctr NANOTAM, TR-06800 Ankara, Turkey
- 2. Morgan State Univ, Dept Chem, Baltimore, MD 21251 USA
Description
In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, the identical bioassay took less than 2 min to complete by using SRR structures (with microwave heating). A lower detection limit of 0.01 nM for biotinylated-bovine serum albumin (100-fold lower than the room temperature bioassay) was observed by using SRR structures. (C) 2010 American Institute of Physics. [doi:10.1063/1.3484958]
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