A novel SPECT/MRI bimodal imaging probe: <SUP>99m</SUP>Tc-DPAPA-Fe₃O₄ nanoconjugate

This study aimed to create a novel bimodal probe. For this purpose, cubic iron oxide nanoparticles (C-Fe3O4 NPs) conjugated with an EDTMP derivative called DPAPA thought to be a targeting tool for prostate cancer and bone metastases were studied. NPs were synthesized and conjugated with DPAPA, and then characterization studies were carried out. The particles were demonstrated to be cubic shaped, with an average size of 68.55 +/- 1 0.03 (n = 3) nm. Then the nanoconjugates were radiolabeled with Tc-99m. In vitro cellular affinities were conducted using PC-3, RWPE-1, LNCaP, K562, and Saos-2 cell lines. In conclusion, radio-nanoconjugates have the potential for bimodal MRI/SPECT imaging.