Synthesis, characterization and biological evaluation of some novel sulfonylurea derivatives
Creators
- 1. Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34854 Istanbul, Turkiye
- 2. Mugla Sitki Kocman Univ, Fac Sci, Dept Chem, TR-48121 Mugla, Turkiye
- 3. Mugla Sitki Kocman Univ, Koycegiz Vocat Sch, Dept Med & Aromat Plants, TR-48800 Mugla, Turkiye
Description
In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR,1H-NMR,13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and beta-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, alpha-amylase and alpha-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against alpha-amylase enzyme with IC50 values of 227.84 +/- 1.48298.27 +/- 8.61 mu M. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs.
Files
bib-7a48a93e-b2b3-4f16-85ee-7f1f2fb15993.txt
Files
(255 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:52d8b86db38831e82da6539e3fd22dcd
|
255 Bytes | Preview Download |