Published January 1, 2010
| Version v1
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Synthesis and biological evaluation of (S)-4-aminoquinazoline alcohols
Creators
- 1. Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey
- 2. Erzincan Univ, Fac Arts & Sci, Dept Chem, TR-24100 Erzincan, Turkey
- 3. Kills 7 Aral Univ, Fac Sci & Letters, Dept Chem, TR-79100 Kilis, Turkey
- 4. Osmaniye Korkut Ata Univ, Fac Sci & Letters, Dept Chem, TR-80100 Osmaniye, Turkey
- 5. Ataturk Univ, Fac Sci, Dept Biol, TR-25240 Erzurum, Turkey
Description
A simple synthetic method for the preparation of enantiomerically pure (S)-4-aminoquinazoline alcohols from (S)-quinazolinone alcohols by key steps including chlorination, nucleophilic ipso substitution, and deacetylation is presented. Mutagenic and antimutagenic properties of the (S)-4-aminoquinazoline alcohols were investigated by using Salmonella typhimurium TA1535, and Escherichia colt WP2uvrA tester strains at 0.01, 0.1, and 1 mu g/plate concentrations. (S)-4-aminoquinazoline alcohols were found to be genotoxically safe at the tested concentrations. Among the tested (S)-4-aminoquinazoline alcohols, the best antimutagenic activity was obtained with a methyl derivative at 0.1 mu g/plate dose. (C) 2010 Elsevier Ltd. All rights reserved.
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