Published January 1, 2022
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Collagen Type I Induces a Balance in the Expression of Anti- and Pro-Apoptotic Genes in Hepatocellular Carcinoma Cells
Creators
- 1. Maltepe Univ, Canc & Stem Cell Res Ctr, Istanbul, Turkey
Description
Background: The importance of extracellular matrix (ECM) components in the progression of hepatocellular carcinoma (HCC) has been shown in many studies. Although restoring or activating apoptosis in tumors is an active area of cancer research, little is known regarding the effects of collagen type I, the main ECM component in the liver, on apoptosis of HCC cells. Here, we investigated the apoptotic profiles of HCC cells in a microenvironment with collagen type I.
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