Yayınlanmış 1 Ocak 2022
| Sürüm v1
Dergi makalesi
Açık
An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge
Oluşturanlar
- 1. Bezmialem Vakif Univ, Beykoz Inst Life Sci & Biotechnol, Aly Lab, TR-34820 Istanbul, Turkey
- 2. Bezmialem Vakif Univ, Beykoz Inst Life Sci & Biotechnol, Microbiol Lab, TR-34820 Istanbul, Turkey
Açıklama
Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans.
Dosyalar
bib-87a8b223-6a86-4453-94e7-9dcc5889b355.txt
Dosyalar
(287 Bytes)
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