Published January 1, 2022
| Version v1
Journal article
Open
An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge
Creators
- 1. Bezmialem Vakif Univ, Beykoz Inst Life Sci & Biotechnol, Aly Lab, TR-34820 Istanbul, Turkey
- 2. Bezmialem Vakif Univ, Beykoz Inst Life Sci & Biotechnol, Microbiol Lab, TR-34820 Istanbul, Turkey
Description
Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans.
Files
bib-87a8b223-6a86-4453-94e7-9dcc5889b355.txt
Files
(287 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:149b07cd424aa6bc77af7e0282b25304
|
287 Bytes | Preview Download |