Yayınlanmış 1 Ocak 2022
| Sürüm v1
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Açık
Synthesis of the bioactive fungal natural product daldiquinone
Oluşturanlar
- 1. Bilkent Univ, Fac Sci, Dept Chem, TR-06800 Ankara, Turkey
Açıklama
We report the first total synthesis of the biologically active fungal natural product daldiquinone (5), which was accomplished with a longest linear sequence of 8 steps in 41% overall yield. The construction of the unsymmetrical binaphthalene core was realized by a Suzuki-Miyaura cross-coupling in 88% yield on gram scale. Oxidation of naphthol 17 with IBX afforded the key naphthoquinone intermediate 18 in high yield (92%). (C) 2022 Elsevier Ltd. All rights reserved.
Dosyalar
bib-28cf4e02-480b-4b64-a9af-e0c8690ce420.txt
Dosyalar
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