Published January 1, 2022
| Version v1
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Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis
Creators
- Zhang, Yun1
- Donaher, Joana Liu1
- Das, Sunny1
- Li, Xin1
- Reinhardt, Ferenc1
- Krall, Jordan A.1
- Lambert, Arthur W.1
- Thiru, Prathapan1
- Keys, Heather R.1
- Khan, Mehreen1
- Hofree, Matan2
- Wilson, Molly M.
- Yedier-Bayram, Ozlem3
- Lack, Nathan A.
- Onder, Tamer T.3
- Bagci-Onder, Tugba3
- Tyler, Michael4
- Tirosh, Itay4
- Regev, Aviv
- Lees, Jacqueline A.
- Lees, Jacqueline A.
- 1. Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA
- 2. Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA
- 3. Koc Univ, Sch Med, Istanbul, Turkey
- 4. Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel
Description
Through genome-wide and focused CRISPR screens, Zhang et al. discover that loss of PRC2 or KMT2D-COMPASS enables distinct EMT trajectories, which exert differential effects on the metastatic capability of carcinoma cells.
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