Yayınlanmış 1 Ocak 2022
| Sürüm v1
Dergi makalesi
Açık
Folic acid conjugated PAMAM-modified mesoporous silica-coated superparamagnetic iron oxide nanoparticles for potential cancer therapy
Oluşturanlar
- 1. Pim Grup Cosmet Consultancy, TR-34077 Istanbul, Turkey
- 2. Istanbul Tech Univ, Dept Chem, Fac Sci, TR-34050 Istanbul, Turkey
- 3. Biruni Univ, Dept Biochem, Fac Pharm, TR-34010 Istanbul, Turkey
- 4. Istanbul Univ, Dept Biomed Engn, TR-34500 Istanbul, Turkey
- 5. Bakircay Univ, Dept Biomed Engn, Fac Engn & Architecture, TR-35665 Izmir, Turkey
- 6. SANKARA Brain & Biotechnol Res Ctr, TR-34320 Istanbul, Turkey
Açıklama
In this study, novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery agents for photodynamic therapy applications. The surface of the magnetic nanoparticles was coated with mesoporous silica (M-MSN). The M-MSN nanoparticles were functionalized with siloxane-cored PAMAM dendrons (generation 1 to 3). The surface of the M-MSN-PAMAM nanocarriers was targeted with folic acid. Indocyanine green (ICG) a near-infrared dye was loaded in the M-MSN-PAMAM nanocarriers and the photodynamic therapy efficiency of the drug-loaded nanocarriers was evaluated on MCF-7 cells.
Dosyalar
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Dosyalar
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