Published January 1, 2022
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Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden
Creators
- 1. Marmara Univ, Dept Physiol, Sch Med, Basibuyuk Mah Maltepe Basibuyuk Yolu 9-1, TR-34854 Istanbul, Turkey
- 2. Marmara Univ, Sch Med, Istanbul, Turkey
- 3. Marmara Univ, Dept Histol & Embryol, Sch Med, Istanbul, Turkey
- 4. Marmara Univ, Dept Med Lab Tech, Vocat Sch Hlth Serv, Istanbul, Turkey
- 5. Marmara Univ, Dept Med Biol, Sch Med, Istanbul, Turkey
- 6. Marmara Univ, Dept Biochem, Sch Med, Istanbul, Turkey
Description
Phoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol/kg, or 45 nmol/kg) daily for 3 days 1 week after STZ injection. Fasting blood glucose (FBG) and gastric emptying rate (GER) were measured. Tissue and blood samples were collected. PNX treatments prevented pancreatic damage and beta cell loss. Increased luminol and lucigenin levels in the pancreas, ileum and liver tissues of STZ groups were alleviated by PNX treatment in pancreatic and ileal tissues. PNX0.45 decreased FBG without any change in insulin blood level and pancreatic mRNA. GER increased in all diabetic rats while PNX0.45 delayed GER only in the C group. PNX diminishes pancreatic damage and lowers FBG by reducing oxidative load.
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