Published January 1, 2022
| Version v1
Journal article
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Chloroquine Decreased Kir6.2 Immunoreactivity in Chronic Hypoxic Heart
Creators
- 1. Yozgat Bozok Univ, Fac Med, Yozgat, Turkey
- 2. Yozgat Bozok Univ, Fac Med, Dept Histol & Embryol, Yozgat, Turkey
- 3. Erciyes Univ, Fac Sci, Dept Biol, Kayseri, Turkey
- 4. Erciyes Univ, Fac Med, Dept Physiol, Kayseri, Turkey
- 5. Pamukkale Univ, Fac Med, Dept Histol & Embryol, Denizli, Turkey
- 6. Erciyes Univ, Fac Med, Dept Histol & Embryol, Kayseri, Turkey
- 7. Univ Hlth Sci Turkey, Int Med Fac, Dept Biophys, Istanbul, Turkey
Description
Objective: Experimental and clinical studies indicate that cardiovascular system diseases have the highest mortality rate. One of the major factors underlying this high mortality rate is hypoxia. The inward rectifying potassium channel 6.2 (Kir6.2) plays a key role in the adaptation and metabolic regulation of cardiac tissue to hypoxia. In this study, the effect of chloroquine on Kir6.2 expression in heart tissue exposed to moderate chronic hypoxia was investigated.
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