Yayınlanmış 1 Ocak 2022
| Sürüm v1
Dergi makalesi
Açık
Synthesis of Ethynyl-Thiophene Derivatives, Antioxidant Properties and ADME Analysis
Oluşturanlar
- 1. Van Yuzuncu Yil Univ, Fac Sci, Dept Chem, TR-65000 Van, Turkey
- 2. Van Yuzuncu Yil Univ, Fac Sci, Dept Mol Biol & Genet, TR-65000 Van, Turkey
- 3. Eskisehir Osmangazi Univ, Fac Sci & Arts, Dept Chem, TR-26040 Eskisehir, Turkey
Açıklama
Herein, novel alkyne based organic compounds, 2-((2-(methylthio)phenyl)ethynyl)thiophene (MAT) and 2-ethynyl-3-(phenylethynyl)thiophene (DAT), were designed and synthesized via Pd-catalyst cross-coupling reactions. The isolated yields of MAT and DAT were obtained as 77 % and 96 %, respectively. After chemical characterization, radical scavenging activities and reduction power capacities of them were determined by DPPH, TEAC, phosphomolybdenum and reducing power methods. MAT showed higher radical scavenging activities than DAT, and comparable with the standard. Moreover, basic ADME properties were calculated in silico. Both of the newly synthesized derivatives were reported with the same moderate to good drug score of 0.42; and, having potential to pass through BBB and GI with no appointed toxic effects.
Dosyalar
bib-8164c26b-dcdc-48d3-b7f8-6cabf71c1a3c.txt
Dosyalar
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