Published January 1, 2022 | Version v1
Journal article Open

Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats

  • 1. Demiroglu Bilim Univ, Dept Physiol, Fac Med, Istanbul, Turkey
  • 2. Lund Univ, Dept Expt Med Sci, Brain Repair & Imaging Neural Syst BRAINS Unit, Lund, Sweden

Description

Objective: Basal ganglia structures play an important role in the pathophysiology of absence epilepsy, known as remote control of absence seizures. We examined the role of the nigrostriatal dopaminergic pathway in absence epilepsy through behavioral and electroencephalography (EEG) parameters, immunohistochemical, and biochemical characteristics of dopamine and serotonin in the genetic absence epilepsy rat model.

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