Yayınlanmış 1 Ocak 2022 | Sürüm v1
Dergi makalesi Açık

Cooperative allostery and structural dynamics of streptavidin at cryogenic- and ambient-temperature

  • 1. Koc Univ, Dept Mol Biol & Genet, TR-34450 Istanbul, Turkey
  • 2. DESY, Notkestr 85, D-22607 Hamburg, Germany
  • 3. SLAC Natl Lab, Stanford PULSE Inst, Menlo Pk, CA 94025 USA
  • 4. SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA

Açıklama

Ayan et al. report two structures of the protein streptavidin - one at ambient temperature determined using serial femtosecond crystallography and a second one determined at cryogenic temperature. These results provide insights into the structural dynamics of apo streptavidin and reveal a cooperative allostery between monomers for binding to biotin, and the findings are supported by GNM analysis.

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