The Cytotoxic and Genotoxic Assays of Mg-Ag Alloy Doped with Zn, Ca, and Nd Elements

Magnesium alloys are being studied for their potential as biodegradable metals, and there is a growing need for multipurpose materials, such as those with more than one use. Binary Mg-Ag alloys were developed as implant materials, combining the beneficial qualities of magnesium with silver's well-known compatibility feature. The result shows that as the amount of the added Ag in the cast alloys increased, the secondary phases (Mg4Ag and Mg54Ag17) that appeared in the structure became more pronounced, and the grains became finer. The best percentage of Ag was found to be 3%, so Ca, Zn and Nd were added, and a study of the biocompatible Mg-3Ag alloy's cytotoxicity and genotoxicity showed that the alloy is safe for cells. In conclusion, 1/1 (total material concentration) cell viability for QE-30, QZ-30, QX-30, and QZEX3000 was 79.39 +/- 1.85, 106.46 +/- 1.99, 93.55 +/- 2.4, and 141.76 +/- 2.71%, respectively. Reducing material concentration by 50% (application at 1/2 concentration) raised viability to 96.83 +/- 1.35, 108.40 +/- 1.92, 124.71 +/- 2.76, and 129.05 +/- 3.5%, indicating the as-cast Mg + 3%Ag + 0.5% Nd-Ca-Zn alloy was extremely biocompatible.