Published January 1, 2010
| Version v1
Journal article
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The Ability to Generate Senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity
Creators
- 1. Bilkent Univ, BilGen Genet & Biotechnol Ctr, Dept Mol Biol & Genet, Ankara, Turkey
- 2. Ankara Numune Res & Teaching Hosp, Dept Surg, Ankara, Turkey
Description
Background: Breast cancer is a remarkably heterogeneous disease. Luminal, basal-like, "normal-like", and ERBB2+ subgroups were identified and were shown to have different prognoses. The mechanisms underlying this heterogeneity are poorly understood. In our study, we explored the role of cellular differentiation and senescence as a potential cause of heterogeneity.
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