Yayınlanmış 1 Ocak 2021
| Sürüm v1
Dergi makalesi
Açık
Enantioselective Friedel-Crafts alkylation of indole with nitroalkenes in the presence of bifunctional squaramide organocatalysts
Oluşturanlar
- 1. Middle East Tech Univ, Dept Chem, TR-06800 Ankara, Turkey
Açıklama
A series of chiral bifunctional quinine and 2-aminoDMAP based squaramide organocatalysts are evaluated in Friedel-Crafts alkylation of indoles with nitroolefins. These 3-substituted indole derivatives are synthesized in the presence of sterically encumbered tert-butyl squaramide/quinine with high enantioselectivity (up to >99% ee) and moderate chemical yields (up to 80%) by representing as chiral precursors for very important biologically active molecules. Besides, this asymmetric transformation provides a very simple, efficient, clean and environmental friendly route. In addition, this process has very mild reaction conditions such as ambient temperature and usage of only 2 mol% catalyst loading compared to previous studies in literature. (C) 2021 Elsevier Ltd. All rights reserved.
Dosyalar
bib-16f8b1da-20ad-4461-9444-78b341a95ee9.txt
Dosyalar
(194 Bytes)
| Ad | Boyut | Hepisini indir |
|---|---|---|
|
md5:e6b150a9a8d12f70c35ea1a461baffb7
|
194 Bytes | Ön İzleme İndir |