Yayınlanmış 1 Ocak 2021
| Sürüm v1
Dergi makalesi
Açık
Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression
Oluşturanlar
- 1. Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey
Açıklama
The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8(+) T cells by activating adenosine receptors. The cytokine interleukin-7 (IL-7), which is produced by various tissues and tumors, promotes the survival and maintenance of T cells. Adenosine and IL-7 signaling are being clinically targeted separately or in combination with other therapies for solid tumor indications. Here, we found that IL-7 signaling promoted the accumulation of tumor-associated CD8(+) T cells, in part, by preventing adenosine-mediated immunosuppression. Inhibition of the transcription factor FoxO1 downstream of IL-7 receptor signaling was important for protecting CD8(+) T cells from suppression by adenosine. These findings have implications for the development of new approaches for cancer immunotherapies that target the adenosine pathway.
Dosyalar
bib-d800e12f-4ca4-476c-87a8-c0ecf6ffe95e.txt
Dosyalar
(185 Bytes)
| Ad | Boyut | Hepisini indir |
|---|---|---|
|
md5:78509ec38489030cb955de77c94ee16c
|
185 Bytes | Ön İzleme İndir |