Published January 1, 2021
| Version v1
Journal article
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CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer
Creators
- 1. Bilkent Univ, Interdisciplinary Program Neurosci, TR-06800 Ankara, Turkey
- 2. Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, Ankara, Turkey
Description
Purpose Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of breast cancer cells. However, modulation of CHRNA5 expression in the context of estrogen signaling and its prognostic implications in breast cancer remained unexplored.
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