Published January 1, 2021
| Version v1
Journal article
Open
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids
Creators
- 1. Ege Univ, Dept Pharmaceut Biotechnol, Izmir, Turkey
- 2. Izmir Univ Econ, Fac Engn, Dept Genet & Bioengn, Izmir, Turkey
Description
Background: siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, and effective carriers are needed.
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