Published January 1, 2021
| Version v1
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IRF5 inhibits prostate cancer metastasis and drug resistance by decreasing CXCR4/CXCL12 complex
- 1. Adnan Menderes Univ, Dept Med Biochem, Sch Med, Aydin, Turkey
- 2. Adnan Menderes Univ, Grad Sch Hlth Sci, Dept Med Biochem, Aydin, Turkey
Description
Purpose: Prostate cancer is the most common type of cancer in men, and drug resistance is typical in its treatment. Chemokines especially play a role in tumor growth and drug resistance mechanisms. IRF5 is a critical transcription factor in immune response, and its relationship with the chemokine family CXCR4 and CXCL12 was investigated in this study.
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