Published January 1, 2021
| Version v1
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Electrochemical Biosensor Design with Multi-walled Carbon Nanotube to Display DNA-Schiff Base Interaction
Creators
- 1. Ankara Univ, Fac Pharm, Dept Analyt Chem, TR-06560 Ankara, Turkey
- 2. Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Etiler Ankara, Turkey
- 3. Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
Description
This paper demonstrates a Schiff base i. e. 5-(diethylamino)-2-((2,6-diethylphenylimino)methyl)phenol (5-DDMP) that was sensed by DNA biosensor. dsDNA was immobilized onto GCE modified with functionalized multi-walled carbon nanotubes to prepare a biosensor. The efficiency of dsDNA biosensor was determined and binding of 5-DDMP with dsDNA was searched by UV-vis spectrophotometry and differential pulse voltammetry. Molecular docking simulations between 5-DDMP and dsDNA were explored and as a result, a hydrogen bond and a pi-pi contact were observed between 5-DDMP and deoxyguanosine base (dG22) of the strand B, deoxyadenosine base (dA5) of the strand A, respectively. These studies could be useful for new anticancer drug design and development.
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