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Published January 1, 2021 | Version v1
Journal article Open

PROGRESS STUDY: Progression of chronic kidney disease in children and heat shock proteins

Creators

  • 1. Istanbul Univ, Div Pediat Nephrol, Istanbul Fac Med, TR-34390 Istanbul, Turkey
  • 2. Istanbul Univ, Dept Med Biol, Istanbul Fac Med, TR-34390 Istanbul, Turkey
  • 3. Marmara Univ, Fac Med, Div Pediat Nephrol, Istanbul, Turkey
  • 4. Kanuni Sultan Suleyman Educ & Res Hosp, Div Pediat Nephrol, Istanbul, Turkey
  • 5. Sisli Etfal Educ & Res Hosp, Div Pediat Nephrol, Istanbul, Turkey
  • 6. Trakya Univ, Sch Med, Div Pediat Nephrol, Edirne, Turkey
  • 7. Bagcilar Educ & Res Hosp, Div Pediat Nephrol, Istanbul, Turkey
  • 8. Istanbul Univ Cerrahpasa, Cerrahpasa Med Sch, Div Pediat Nephrol, Istanbul, Turkey
  • 9. Bakirkoy Sadi Konuk Educ & Res Hosp, Div Pediat Nephrol, Istanbul, Turkey
  • 10. Kartal Educ & Res Hosp, Div Pediat Nephrol, Istanbul, Turkey
  • 11. Koc Univ, Sch Med, Div Pediat Nephrol, Istanbul, Turkey

Description

Various molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with the clinical parameters of CKD in children. In total, 117 children with CKD and 56 healthy children were examined. The CKD group was followed up prospectively for 24 months. Serum and urine HSP27, HSP40, HSP47, HSP60, HSP70, HSP72, and HSP90 levels and serum anti-HSP60 and anti-HSP70 levels were measured by ELISA at baseline, 12 months, and 24 months. The urine levels of all HSPs and the serum levels of HSP40, HSP47, HSP60, HSP70, anti-HSP60, and anti-HSP70 were higher at baseline in the CKD group than in the control group. Over the months, serum HSP47 and HSP60 levels steadily decreased, whereas HSP90 and anti-HSP60 levels steadily increased. Urine HSP levels were elevated in children with CKD; however, with the exception of HSP90, they decreased over time. In conclusion, our study demonstrates that CKD progression is a complicated process that involves HSPs, but they do not predict CKD progression. The protective role of HSPs against CKD may weaken over time, and HSP90 may have a detrimental effect on the disease course.

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