The Microencapsulation of Terbinafine via In Situ Polymerization of Melamine-Formaldehyde and Their Application to Cotton Fabric

In this study an antifungal pharmaceutical agent, terbinafine, was microencapsulated by using in situ polymerization. The polymerization was carried out at four mole ratio level and preparations were applied to the 100% cotton fabric. X-ray diffractometry, DSC, FTIR, BET, contact angle measurements, particle size distribution and imaging techniques were performed. Best results were obtained in the case of 8 : 1 mole ratio. Strength of microcapsule applied fabrics to washing and fungus were also determined. After 25 washing cycle, microcapsules were still in the fabric and had antifungal properties against A. niger. Antifungal strength against T. rubrum was observed up to 15 washing cycles. (C) 2010 Wiley Periodicals, Inc. I Appl Polym Sci 118: 3707-3714, 2010