Published January 1, 2021
| Version v1
Journal article
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Lesional activation of T(c)17 cells in Behcet disease and psoriasis supports HLA class I-mediated autoimmune responses
Creators
- 1. Univ Hosp, Ludwig Maximilian Univ Munich, Dept Dermatol & Allergy, D-80337 Munich, Germany
- 2. Ankara Univ, Dept Dermatol, TR-06100 Ankara, Turkey
- 3. Ankara Univ, Dept Pathol, TR-06100 Ankara, Turkey
Description
Background Behcet disease (BD) presents with lymphocytic and neutrophilic vasculitis of unknown aetiology. HLA-B*51, the endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin 23 receptor (IL23R)/IL12R are genetic risk factors. IL-23 regulates IL-17A, which controls the recruitment and activation of neutrophils.
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