Yayınlanmış 1 Ocak 2021
| Sürüm v1
Dergi makalesi
Açık
Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction
Oluşturanlar
- 1. Penn State Univ, Biomed Engn, University Pk, PA 16802 USA
- 2. Kyung Hee Univ, Sch Dent, Dept Dent Mat, Seoul 02447, South Korea
- 3. Penn State Univ, Dept Neurosurg, Hershey, PA 17033 USA
- 4. Penn State Univ, Dept Surg, Hershey, PA 17033 USA
- 5. Penn State Univ, Dept Mech Engn, University Pk, PA 16802 USA
- 6. Cukurova Univ, Ceyhan Engn Fac, Mech Engn Dept, TR-01950 Adana, Turkey
Açıklama
Reconstruction of complex craniomaxillofacial (CMF) defects is challenging due to the highly organized layering of multiple tissue types. Such compartmentalization necessitates the precise and effective use of cells and other biologics to recapitulate the native tissue anatomy. In this study, intra-operative bioprinting (IOB) of different CMF tissues, including bone, skin, and composite (hard/soft) tissues, is demonstrated directly on rats in a surgical setting. A novel extrudable osteogenic hard tissue ink is introduced, which induced substantial bone regeneration, with approximate to 80% bone coverage area of calvarial defects in 6 weeks. Using droplet-based bioprinting, the soft tissue ink accelerated the reconstruction of full-thickness skin defects and facilitated up to 60% wound closure in 6 days. Most importantly, the use of a hybrid IOB approach is unveiled to reconstitute hard/soft composite tissues in a stratified arrangement with controlled spatial bioink deposition conforming the shape of a new composite defect model, which resulted in approximate to 80% skin wound closure in 10 days and 50% bone coverage area at Week 6. The presented approach will be absolutely unique in the clinical realm of CMF defects and will have a significant impact on translating bioprinting technologies into the clinic in the future.
Dosyalar
bib-2e43677a-99d0-4b82-85de-561a869aacb9.txt
Dosyalar
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