Published January 1, 2021
| Version v1
Journal article
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Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis
Creators
- 1. Ankara Educ & Res Hosp, Dept Internal Med, Ankara, Turkey
- 2. Ankara Univ, Biotechnol Inst, Ankara, Turkey
- 3. Bilkent Univ, Dept Mol Biol & Genet, Ankara, Turkey
- 4. Baskent Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkey
- 5. Med Pk Ankara Hosp, Dept Nephrol, Ankara, Turkey
- 6. Koru Hosp, Dept Nephrol, Ankara, Turkey
- 7. Phys Private Nephrol Clin, Ankara, Turkey
Description
Aims: Focal segmental glomerulosclerosis (FSGS) is the common cause of chronic renal disease worldwide. Although there are many etiologic factors which have common theme of podocyte injury conclusive etiology is not clearly understood. In this study, we aimed to explore the role of autophagy in the pathogenesis of podocyte injury, which is the key point in disease progression, and the roles of intrarenal microRNAs and the prorenin receptor (PRR) in the 5/6 nephrectomy and adriamycin nephropathy models of FSGS.
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