Published January 1, 2021 | Version v1
Journal article Open

Periodontitis and peri-implantitis tissue levels of Treponema denticola-CTLP and its MMP-8 activating ability

  • 1. Univ Turku, Inst Dent, Dept Periodontol, Lemminkaisenkatu 2, Turku 20520, Finland
  • 2. Istanbul Univ Cerrahpasa, Fac Dent, Dept Periodontol, Istanbul, Turkey
  • 3. Istanbul Univ, Fac Dent, Dept Periodontol, Istanbul, Turkey

Description

Background and Aims: Chymotrypsin-like-proteinase of Treponema denticola (Td-CTLP) can stimulate the protein expression and activation of matrix metalloproteinase (MMP)-8 (or collagenase-2), a potent tissue destructive enzyme from gingival cells in vitro. The aims of this study were 1) to demonstrate the proMMP-8 (or latent MMP-8) activation by Td-CTLP in vitro and 2) to detect Td-CTLP and MMP-8 protein levels in the tissue samples of peri-implantitis and periodontitis patients.

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