Published January 1, 2021 | Version v1
Journal article Open

White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers

  • 1. Radboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, Nijmegen, Netherlands
  • 2. Radboud Univ Nijmegen, Radboud Alzheimer Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol,Med Ctr, Nijmegen, Netherlands
  • 3. Radboud Univ Nijmegen, Radboud Alzheimer Ctr, Donders Inst Brain Cognit & Behav, Dept Geriatr,Med Ctr, Nijmegen, Netherlands
  • 4. Fdn IRCCS Ca Granda, Osped Policlin, Milan, Italy
  • 5. Univ Lisbon, Fac Med, Lisbon, Portugal
  • 6. Univ Perugia, Ctr Memory Disturbances, Sect Neurol, Perugia, Italy
  • 7. Univ Milan, Dino Ferrari Ctr, Milan, Italy

Description

Background: The cerebrospinal fluid (CSF) biomarkers amyloid-beta 1-42 (A beta(42)), total and phosphorylated tau (t-tau, p-tau) are increasingly used to assist in the clinical diagnosis of Alzheimer's disease (AD). However, CSF biomarker levels can be affected by confounding factors.

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