Yayınlanmış 1 Ocak 2021
| Sürüm v1
Dergi makalesi
Açık
One-pot synthesis of alpha,beta-unsaturated ketones through sequential alkyne dimerization/hydration reactions using the Hoveyda-Grubbs catalyst
Oluşturanlar
- 1. Hacettepe Univ, Fac Sci, Chem Dept, TR-06800 Beytepe, Turkey
Açıklama
Herein we report a sequential one-pot alkyne dimerization/hydration protocol for the regioselective synthesis of alpha,beta-unsaturated ketones in quantitative yields. The alkyne dimerization reactions of terminal arylacetylenes proceeded with high regioselectivity in the presence of the Hoveyda-Grubbs 2nd generation catalyst (1 mol%) and tricyclohexylphosphine (4 mol%). The hydration reactions of in situ formed 1-aryl-3-en-1-ynes proceeded very rapidly in the presence of CCl3COOH/p-TsOH center dot H2O, yielding the corresponding unsaturated ketones within 15 minutes in quantitative yields. Different arylacetylene derivatives were converted to the corresponding alpha,beta-unsaturated ketones in quantitative yields (94-95%) using sequential one-pot alkyne dimerization/hydration reactions.
Dosyalar
bib-9396e15b-c5f2-4275-8285-33b5a663ac64.txt
Dosyalar
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