Yayınlanmış 1 Ocak 2021
| Sürüm v1
Dergi makalesi
Açık
A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking
Oluşturanlar
- 1. Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA
- 2. Weill Cornell Med Coll, Mol Imaging Innovat Inst, Dept Radiol, New York, NY 10065 USA
- 3. Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program HOPP, New York, NY 10065 USA
- 4. Mem Sloan Kettering Canc Ctr, Mol Cytol Core Facil, New York, NY 10065 USA
Açıklama
Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodistribution and fate following infusion. To this end, we developed a dual-modal PET/near infrared fluorescent (NIRF) nanoparticlebased imaging agent for non-genomic labeling of human CAR T cells. Since the PET/NIRF nanoparticles did not affect cell viability or cytotoxic functionality and enabled long-term whole-body CAR T cell tracking using PET and NIRF in an ovarian peritoneal carcinomatosis model, this platform is a viable imaging technology to be applied in other cancer models.
Dosyalar
bib-f293fada-c9a1-4bb8-8f69-0aacc91710db.txt
Dosyalar
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