Published January 1, 2021
| Version v1
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Targeting oncogenic WIP1 phosphatase sensitizes hypoxic breast cancer cells to doxorubicin induced apoptosis via activation of p53-p21 axis
Creators
- 1. Univ Aydin Adnan Menderes, Fac Med, Dept Med Biol, Aytepe Campus, Aydin, Turkey
Description
Background: Oncogenic PPM1D/Wip1 phosphatase is negative regulator of chemotherapy responses. Hypoxia is a common feature of solid tumors associated with poor prognosis and resistance to radiotherapy and chemotherapy.
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