Published January 1, 2021
| Version v1
Journal article
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Effects of sitagliptin on beta-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta
Creators
- 1. Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey
- 2. Bezmialem Vakif Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkey
Description
Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. beta(2)-adrenoceptors (beta(2)-ARs) mediate the vasorelaxation in the aorta. However, beta(3)-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on beta(2)- and beta(3)-adrenoceptor-mediated relaxations in the diabetic rat aorta.
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