Yayınlanmış 1 Ocak 2011
| Sürüm v1
Dergi makalesi
Açık
The Synthesis of Epiboxidine and Related Analogues as Potential Pharmacological Agents
Oluşturanlar
- 1. Yildiz Tech Univ, Fac Art & Sci, Dept Chem, TR-34210 Istanbul, Turkey
Açıklama
Methyl epiboxidine-N-carboxylate (8) was synthesized from 7 under reductive Heck conditions (Scheme 2). The C?C coupling of the new epiboxidine analog 9 with aryl and heteroaryl halides gave by hydroarylation C-aryl, N-(3-methylisoxazol-5-yl)-substituted tricyclic imides 10a10f (Table). The [3+2] cycloaddition of 9 with nitrile oxides yielded the bridged dihydroisoxazole derivatives 11a11d with potential biological activity (Scheme 4).
Dosyalar
bib-8f56aec4-e21b-4776-aed0-3f419115b0d7.txt
Dosyalar
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