Published January 1, 2011
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A set of highly water-soluble tetraethyleneglycol-substituted Zn(II) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity
Creators
- 1. Gebze Inst Technol, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey
- 2. Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada
- 3. Univ Lyon 1, CNRS, UMR 5246, Ctr Commun Spectrometrie Masse, F-69622 Villeurbanne, France
- 4. Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, Yorks, England
Description
Three Zn(II) phthalocyanines substituted by hydroxyl-terminated tetraethylene glycol chains have been synthesized. In order to evaluate the potential of these highly water-soluble phthalocyanines as type II-photosensitisers for photodynamic therapy, their structure-activity relationship was assessed by determining relevant photophysical and photochemical properties, such as their aggregation behaviour in aqueous buffers, their fluorescence properties and their efficiency with regard to the generation of singlet oxygen. In addition, evidence for a negligible interaction with plasma proteins in undiluted human plasma was obtained using a recently developed bioanalytical method and compared with the fluorescence quenching approach. These results combined with in vitro data regarding the phototoxicity of these phthalocyanines against HT-29 cancer cells provide evidence for the relevance of the non-peripherally substituted derivative for further in vivo investigations.
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