Published January 1, 2011
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Cyclooxygenase-2 Polymorphisms and Pancreatic Cancer Susceptibility
- 1. Istanbul Univ, Fac Pharm, Dept Pharmaceut Toxicol, TR-34116 Istanbul, Turkey
- 2. Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
- 3. Newcastle Univ, Dept Surg, Freeman Hosp, Hepatopancreato Biliary Unit, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
Description
Objectives: DNA sequence variants in the cyclooxygenase-2 (COX-2) gene may lead to altered COX-2 production and/or activity, resulting in interindividual differences in susceptibility to pancreatic cancer. To test this hypothesis, we investigated the relationship between polymorphisms in the COX-2 gene and the risk of pancreatic cancer in a European population.
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