Yayınlanmış 1 Ocak 2011
| Sürüm v1
Dergi makalesi
Açık
Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum
Oluşturanlar
- 1. CESI Univ G Annunzio, CINBO, Chieti, Italy
- 2. Hop Paul Brousse, AP HP, Lab Anat & Cytol Pathol, Villejuif, France
Açıklama
Background: ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed. Here, we investigate whether circadian changes in local abcc2 expression participate in the circadian rhythm of irinotecan toxicity for ileum mucosa, and further assess whether genetic background or sex modify this relation.
Dosyalar
bib-36dd8d3d-2f9d-41ce-be31-42a7afae35b2.txt
Dosyalar
(290 Bytes)
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