Yayınlanmış 1 Ocak 2011
| Sürüm v1
Dergi makalesi
Açık
Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic beta Cells
Oluşturanlar
- 1. Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Bratislava, Slovakia
- 2. Gazi Univ, Fac Med, Dept Biochem Med, Ankara, Turkey
- 3. Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey
- 4. Ctr Med Univ Geneva, Dept Internal Med, Div Clin Biochem, Geneva, Switzerland
- 5. Gazi Univ, Fac Med, Dept Med Pharmacol, Ankara, Turkey
Açıklama
The potential protective effect of (+/-)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E beta cells and compared with the effect of the related pyridoindole, stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2.
Dosyalar
bib-d82b06e6-b234-4bbf-afa8-4775179f1799.txt
Dosyalar
(234 Bytes)
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md5:46bbe76c5809a42d61d94eebd6a4de8b
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234 Bytes | Ön İzleme İndir |