Published January 1, 2011
| Version v1
Journal article
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Reliability of basophil activation test using CD203c expression in diagnosis of pollen allergy
Creators
- 1. Ankara Univ, Tip Fak, Gogus Hastaliklari ABD, Immunol & Allerji Hastaliklari BD,Sch Med, TR-06100 Ankara, Turkey
- 2. Ankara Univ, Sch Med, Div Pediat Immunol, TR-06100 Ankara, Turkey
- 3. Ankara Univ, Sch Med, Dept Biostat, TR-06100 Ankara, Turkey
Description
Background: CD203c is a basophil surface marker and its expression is rapidly up-regulated after cross-linking of high-affinity immunoglobulin E (IgE) receptor (FcepsilonR1) by an allergen. CD203c basophil activation tests have been studied for the in vitro diagnosis of several allergic conditions. However, there is limited data about its diagnostic usefulness. The optimum allergen concentrations for stimulation and allergen specific cutoff values remain unknown for a number of allergens. This study was designed to investigate the efficacy of basophil activation test via CD203c in the diagnosis of pollen allergy.
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