Expression of ASC in post-mortem brain samples of Alzheimer's disease patients: A possible role for ASC in A beta amyloid formation

Aim: Amyloid is an extracellular insoluble protein aggregate which accumulates in several tissues in various clinical conditions. The co-localization of ASC, a key molecule in both apoptotic and inflammatory processes, with AA type amyloid fibrils has previously been demonstrated by our group. The aim of this study was to determine whether the distribution of ASC is altered around A beta deposits and senile plaques in post-mortem brain samples of Alzheimer's disease patients.