Published January 1, 2011
| Version v1
Journal article
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Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphisms in Leukemic Hematopoiesis
Creators
- 1. Ankara Univ, Fac Med, Dept Med Genet, TR-06100 Ankara, Turkey
- 2. Ankara Univ, Fac Med, Dept Internal Med, Hematol Unit, TR-06100 Ankara, Turkey
- 3. Ankara Univ, Fac Med, Dept Prevent Oncol, TR-06100 Ankara, Turkey
- 4. Hacettepe Univ, Fac Med, Dept Internal Med, TR-06100 Ankara, Turkey
Description
Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. Angiotensin converting enzyme (ACE) converts angiotensinogen-I to its physiologically active peptide angiotensinII, which stimulates proliferation and differentiation of hematopoietic stem cells through angiotensin II type 1 receptors. We investigated the ACE insertion/deletion (I/D) gene polymorphisms in patients with hematological malignancies including acute and chronic leukemia, myelodysplastic syndrome and multiple myeloma. Our results showed that 80.4% of the patients represented ID/II genotype, whereas it was 55.9% of the control group and 3.2 fold increased disease risk in the existence of insertion allele (ID/II). This is the first study demonstrating possible effects of ACE I/D gene polymorphism of the local bone marrow RAS components on leukemic hematopoiesis.
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