Published January 1, 2011
| Version v1
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Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease
Creators
- 1. Istanbul Univ, Dept Genet, Inst Expt Med, TR-34390 Istanbul, Turkey
- 2. Istanbul Univ, Dept Neurol, Istanbul Fac Med, TR-34390 Istanbul, Turkey
- 3. Acibadem Univ, Dept Neurol, Sch Med, Istanbul, Turkey
- 4. Univ Oxford, Nuffield Dept Clin Neurosci, Neuroimmunol Grp, Oxford OX1 2JD, England
- 5. Istanbul Univ, Div Rheumatol, Dept Internal Med, Istanbul Fac Med, TR-34390 Istanbul, Turkey
- 6. Bilkent Univ, Dept Mol Biol & Genet, Ankara, Turkey
Description
No disease-specific neuronal antibodies have so far been defined in neuro-Behcet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD. (C) 2011 Elsevier B.V. All rights reserved.
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