Published January 1, 2013
| Version v1
Journal article
Open
The first total synthesis of apigenin 7-O--D-cellobiosyl-4-O--D-glucopyranoside isolated from Salvia uliginosa
Creators
- 1. Sakarya Univ, Dept Chem, Fac Arts & Sci, TR-54140 Sakarya, Turkey
- 2. Sakarya Univ, Dept Sci Educ, Fac Educ, TR-54300 Sakarya, Turkey
Description
The first total synthesis of apigenin 7-O--D-cellobioside (5) and apigenin 7-O--D-cellobiosyl-4-O--D-glucopyranoside (8), which were isolated from petals of Salvia patens and Salvia uliginosa, were achieved in four and six steps and 76% and 57%, respectively, overall yield, from naringenin (1). The total synthesis contained two-glycosylation, acetylation, oxidation, selective deacetylation and deprotection steps. Although this route contained six steps, the targeted compounds were obtained with higher yields and easier purifications than other synthetic methods.
Files
bib-0107ce84-5385-4ba0-a516-f6a092e3d443.txt
Files
(244 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:216e0aee87ba72ceeb7aec567792ee0d
|
244 Bytes | Preview Download |