Yayınlanmış 1 Ocak 2013
| Sürüm v1
Dergi makalesi
Açık
Dexmedetomidine ameliorates TNBS-induced colitis by inducing immunomodulator effect
Oluşturanlar
- 1. Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Anesthesiol & Reanimat, TR-44100 Malatya, Turkey
- 2. Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Histol & Embryol, TR-44100 Malatya, Turkey
- 3. Inonu Univ, Turgut Ozal Med Ctr, Fac Med, Dept Med Biol & Genet, TR-44100 Malatya, Turkey
Açıklama
Background: Since sedatives are often administered to immune-compromised and critically ill patients, our understanding of immunomodulation by sedation will be critical. Dexmedetomidine, a selective alpha(2)-adrenergic receptor agonist, is often used for sedation and analgesia especially in intensive care units. There are conflicting and little data concerning both the effect and the mechanism of dexmedetomidine on immune response. In our study, we aimed to investigate the effect of dexmedetomidine on immune system at two different doses (5 mu g.kg(-1) and 30 mu g.kg(-1)) during inflammatory bowel disease by using an experimental model, which resembles both systemic and local inflammation.
Dosyalar
bib-11c481ab-7f3f-4029-81b5-a2599de2dd49.txt
Dosyalar
(231 Bytes)
| Ad | Boyut | Hepisini indir |
|---|---|---|
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md5:7fd65062f50ad973f34da7de9ab030d8
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231 Bytes | Ön İzleme İndir |