Published January 1, 2013
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Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties
Creators
- 1. Gebze Inst Technol, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey
- 2. Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, East Yorks, England
- 3. Univ Lyon 1, Ctr Commun Spectrometrie Masse, CNRS, UMR 5246, F-69622 Villeurbanne, France
Description
Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.
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