Separation of Magnetic Nanoparticles by Cyclical Electrical Field Flow Fractionation

In this study, the potential of Cyclical Electrical Field Flow Fractionation (CyEFFF) for the separation of magnetic nanoparticles is investigated. We demonstrated for the first time that by the application of appropriate voltage waveforms, one can separate gold nanoparticles with sizes less than 50 nm. By using suitable voltage waveforms, the detrimental effect of the particle diffusion is suppressed and particles in the range of 10 nms can be fractionated. In addition, it is shown that CyEFFF is capable of separating lipid and polystyrene sulfonate coated magnetite nanoparticles with the same hydrodynamic radius of 50 nm.