Published January 1, 2013
| Version v1
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Calixarene-based chiral primary amine thiourea promoted highly enantioselective asymmetric Michael reactions of alpha,alpha-disubstituted aldehydes with maleimides
Creators
- 1. Necmettin Erbakan Univ, Dept Chem, TR-42099 Meram, Konya, Turkey
Description
Calix[4]arene based chiral bifunctional thiourea-primary amines have been shown to act as effective catalysts for the Michael addition of aldehydes to maleimides for the first time. The corresponding adducts were generally obtained preferentially in (R)- or (S)-forms with high yields (up to 99%) and with high to excellent enantioselectivities (up to 98% ee). (C) 2013 Elsevier Ltd. All rights reserved.
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