Published January 1, 2013
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Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity
- 1. Yildiz Tech Univ, Fac Sci & Arts, Dept Chem, TR-34210 Esenler, Turkey
Description
The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl(hetaryl), N-[((4-pyrimidin-2-yl) piperazin-1-yl) butyl] substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.
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