Published January 1, 2013
| Version v1
Journal article
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Changes in Gene Methylation Following Chemotherapy in Breast Cancer Cell Lines
- 1. Uludag Univ, Sci & Arts Fac, Dept Biol, TR-16059 Bursa, Turkey
- 2. Tech Univ Munich, M Rechts Isar, Dept Obstet & Gynecol, D-80290 Munich, Germany
- 3. Uludag Univ, Fac Med, Dept Med Biochem, TR-16059 Bursa, Turkey
Description
Objective: Epigenetic modulation of gene expression by DNA promoter methylation may contribute to acquired resistance to chemotherapy in cancer cells. Decitabine (5-aza-2'-deoxycytidine), a demethylating agent, may act synergistically with standard chemotherapy regimens to activate epigenetically silenced genes. In the present in vitro study, it was investigated the effect of gene methylation level after treatment with decitabine and combination of decitabine with anthracycline-based therapeutics (5-fluorouracil plus epirubicine plus cyclophosphamide; FEC) on breast cancer cells (MCF-7 and MDA-MB-231).
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